informasi liyane ― Wong jawa

Urticarial vasculitis minangka kondhisi langka sing ditandhani kanthi episode hives sing tahan suwe utawa bola-bali. Senadyan gejala kulit bisa kaya gatal-gatal kronis, gejala kasebut unik amarga gatal-gatal tetep paling sethithik 24 jam lan bisa nyebabake bintik-bintik peteng sawise ilang. Sanadyan asring sabab sing ora dingerteni, kadhangkala bisa dipicu dening obat-obatan tartamtu, infeksi, penyakit otoimun, kelainan getih, utawa kanker. Sawetara panaliten malah wis nggandhengake karo flu COVID-19 lan H1N1. Uga bisa mengaruhi bagean awak liyane kayata otot, ginjel, paru-paru, weteng, lan mripat. Nalika jinis pemeriksaan jaringan tartamtu bisa ngonfirmasi diagnosis, ora mesthi dibutuhake. Perawatan biasane diwiwiti kanthi antibiotik, dapsone, colchicine, utawa hydroxychloroquine kanggo kasus sing luwih entheng. Kanggo kasus sing luwih abot, obat-obatan sing nyuda sistem kekebalan kaya methotrexate utawa kortikosteroid bisa uga dibutuhake. Bubar, terapi biologis (rituximab, omalizumab, interleukin-1 inhibitors) wis janji kanggo kasus sing angel.
Urticarial vasculitis is a rare clinicopathologic entity that is characterized by chronic or recurrent episodes of urticarial lesions. Skin findings of this disease can be difficult to distinguish visually from those of chronic idiopathic urticaria but are unique in that individual lesions persist for ≥24 hours and can leave behind dusky hyperpigmentation. This disease is most often idiopathic but has been linked to certain drugs, infections, autoimmune connective disease, myelodysplastic disorders, and malignancies. More recently, some authors have reported associations between urticarial vasculitis and COVID-19, as well as influenza A/H1N1 infection. Urticarial vasculitis can extend systemically as well, most often affecting the musculoskeletal, renal, pulmonary, gastrointestinal, and ocular systems. Features of leukocytoclastic vasculitis seen on histopathologic examination are diagnostic of this disease, but not always seen. In practice, antibiotics, dapsone, colchicine, and hydroxychloroquine are popular first-line therapies, especially for mild cutaneous disease. In more severe cases, immunosuppressives, including methotrexate, mycophenolate mofetil, azathioprine, and cyclosporine, as well as corticosteroids, may be necessary for control. More recently, select biologic therapies, including rituximab, omalizumab, and interleukin-1 inhibitors have shown promise for the treatment of recalcitrant or refractory cases.

Wong lanang umur 35 taun teka kanthi riwayat 15 dina kanthi abang padhang, ruam sing nyeri ing paha lan sikil, bebarengan karo nyeri sendi. Dheweke ngalami infeksi saluran kemih seminggu sadurunge muncul ruam. Kulite nuduhake pirang-pirang plak sing lembut, bentuk cincin, sebagian blanchable, abang ing sisih loro paha lan sikil. Dheweke diwenehi prednisolone oral (40mg / dina) sajrone seminggu bebarengan karo antihistamin non-ngantuk (fexofenadine) . Ing seminggu, kabeh rashes ilang. Ora ana ruam maneh sajrone 6 wulan sabanjure mriksa rutin.
A 35-year-old man came in with a 15-day history of bright red, painful rashes on both thighs and legs, along with joint pain. He had a urinary tract infection for a week before the rash appeared. His skin showed several tender, ring-shaped, partially blanchable, red plaques on both sides of his thighs and legs. He was given oral prednisolone (40mg/day) for a week along with a non-drowsy antihistamine (fexofenadine). Within a week, all the rashes disappeared completely. There were no more rashes during the next 6 months of regular check-ups.